HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-fluoro-N'-hydroxybenzene-1-carboximidamide → 1-(Cyclopentylcarbonyl)-3-(4-ethylphenyl)-5-[3-(3-fluorophenyl)-1,2,4-oxadiazol-5-yl]piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-fluoro-N'-hydroxybenzene-1-carboximidamide | HCID 4090972 | — |
| Reactant | 1-(Cyclopentylcarbonyl)-5-(4-ethylphenyl)piperidine-3-carboxylic acid | HCID 46164685 | — |
| Product | 1-(Cyclopentylcarbonyl)-3-(4-ethylphenyl)-5-[3-(3-fluorophenyl)-1,2,4-oxadiazol-5-yl]piperidine | HCID 58002681 | — |
Reaction Steps
66 mg (0.20 mmol) of 1-(cyclopentylcarbonyl)-5-(4-ethylphenyl)piperidine-3-carboxylic acid (Example 7A) and 34 mg (0.22 mmol, 1.1 eq.) of 3-fluoro-N′-hydroxybenzenecarboximidamide were reacted according to the General Method 1. Yield: 47 mg (53% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08119663B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-8b23004e304b4f77a4dd34527df630fe |
| Source note | uspto-grants-2012_02 |