HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-(4-Ethylphenyl)-1-(morpholin-4-ylcarbonyl)piperidine-3-carboxylic acid → 4-({3-(4-Ethylphenyl)-5-[3-(3-methylphenyl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl}carbonyl)-morpholine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-(4-Ethylphenyl)-1-(morpholin-4-ylcarbonyl)piperidine-3-carboxylic acid | HCID 58002225 | — |
| Reactant | 1-Hydroxy-3-methylbenzenecarboximidamide | HCID 66755472 | — |
| Product | 4-({3-(4-Ethylphenyl)-5-[3-(3-methylphenyl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl}carbonyl)-morpholine | HCID 58002377 | — |
Reaction Steps
69 mg (0.20 mmol) of 5-(4-ethylphenyl)-1-(morpholin-4-ylcarbonyl)piperidine-3-carboxylic acid (Example 38A) and 33 mg (0.22 mmol, 1.1 eq.) of 1-hydroxy-3-methylbenzenecarboximidamide were reacted according to the General Method 1. Yield: 16 mg (18% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08119663B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-a7b4253e760b4363b866a01aa86746d2 |
| Source note | uspto-grants-2012_02 |