5-(4-Ethylphenyl)-1-(morpholin-4-ylcarbonyl)piperidine-3-carboxylic acid → HCID 58002602, compound

HRID 1642873Notes

Reaction equation

HRID 1642873 reaction equation
[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([CH:9]2[CH2:14][N:13]([C:15]([N:17]3[CH2:22][CH2:21][O:20][CH2:19][CH2:18]3)=[O:16])[CH2:12][CH:11]([C:23]([OH:25])=O)[CH2:10]2)=[CH:5][CH:4]=1)[CH3:2].O[C:27]1([C:38](=[NH:40])[NH2:39])[CH:32]=[CH:31][CH:30]=[C:29]([O:33][C:34]([F:37])([F:36])[F:35])[CH2:28]1>>[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([CH:9]2[CH2:10][CH:11]([C:23]3[O:25][N:40]=[C:38]([C:27]4[CH:32]=[CH:31][CH:30]=[C:29]([O:33][C:34]([F:35])([F:36])[F:37])[CH:28]=4)[N:39]=3)[CH2:12][N:13]([C:15]([N:17]3[CH2:18][CH2:19][O:20][CH2:21][CH2:22]3)=[O:16])[CH2:14]2)=[CH:5][CH:4]=1)[CH3:2]

Participants

3

Reactant 2

HCID 580022255-(4-Ethylphenyl)-1-(morpholin-4-ylcarbonyl)piperidine-3-carboxylic acidHCID 66755684HCID 66755684, compound

Product 1

HCID 58002602HCID 58002602, compound

Procedure

69 mg (0.20 mmol) of 5-(4-ethylphenyl)-1-(morpholin-4-ylcarbonyl)piperidine-3-carboxylic acid (Example 38A) and 48 mg (0.22 mmol, 1.1 eq.) of 1-hydroxy-3-(trifluoromethoxy)benzenecarboximidamide were reacted according to the General Method 1. Yield: 68 mg (64% of theory)

Sources & evidence

ORD record
ord-4711bd1a38ee4b2aaa1f993c0e6c7c9e
Source dataset
uspto-grants-2012_02
Patent number
US08119663B2

Reaction notes

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