HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-Hydroxypicolinimidamide → 2-{5-[1-(Cyclopentylcarbonyl)-5-(4-ethylphenyl)piperidin-3-yl]-1,2,4-oxadiazol-3-yl}pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-Hydroxypicolinimidamide | HCID 120564 | — |
| Reactant | 1-(Cyclopentylcarbonyl)-5-(4-ethylphenyl)piperidine-3-carboxylic acid | HCID 46164685 | — |
| Product | 2-{5-[1-(Cyclopentylcarbonyl)-5-(4-ethylphenyl)piperidin-3-yl]-1,2,4-oxadiazol-3-yl}pyridine | HCID 58002695 | — |
Reaction Steps
66 mg (0.20 mmol) of 1-(cyclopentylcarbonyl)-5-(4-ethylphenyl)piperidine-3-carboxylic acid (Example 7A) and 30 mg (0.22 mmol, 1.1 eq.) of N′-hydroxypyridine-2-carboximidamide were reacted according to the General Method 1. Yield: 27 mg (30% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08119663B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-f9bbc572ef9a4659afe494d7667e399a |
| Source note | uspto-grants-2012_02 |