HCID 2744266, compound → HCID 58002709, compound

HRID 1642892Notes

Reaction equation

HRID 1642892 reaction equation
[CH:1]1([C:6]([N:8]2[CH2:13][CH:12]([C:14]3[CH:19]=[CH:18][C:17]([CH2:20][CH3:21])=[CH:16][CH:15]=3)[CH2:11][CH:10]([C:22](O)=[O:23])[CH2:9]2)=[O:7])[CH2:5][CH2:4][CH2:3][CH2:2]1.O[N:26]=[C:27]([C:29]1[N:30]=[C:31]([CH3:34])[S:32][CH:33]=1)[NH2:28]>>[CH:1]1([C:6]([N:8]2[CH2:9][CH:10]([C:22]3[O:23][N:28]=[C:27]([C:29]4[N:30]=[C:31]([CH3:34])[S:32][CH:33]=4)[N:26]=3)[CH2:11][CH:12]([C:14]3[CH:15]=[CH:16][C:17]([CH2:20][CH3:21])=[CH:18][CH:19]=3)[CH2:13]2)=[O:7])[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 2744266HCID 2744266, compoundHCID 461646851-(Cyclopentylcarbonyl)-5-(4-ethylphenyl)piperidine-3-carboxylic acid

Product 1

HCID 58002709HCID 58002709, compound

Procedure

66 mg (0.20 mmol) of 1-(cyclopentylcarbonyl)-5-(4-ethylphenyl)piperidine-3-carboxylic acid (Example 7A) and 35 mg (0.22 mmol, 1.1 eq.) of N′-hydroxy-2-methyl-1,3-thiazole-4-carboximidamide were reacted according to the General Method 1. Yield: 36 mg (40% of theory)

Sources & evidence

ORD record
ord-21aaa1be8bbb4be3ac112af2f0993d7d
Source dataset
uspto-grants-2012_02
Patent number
US08119663B2

Reaction notes

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