1-(Cyclopentylcarbonyl)-5-(4-ethylphenyl)piperidine-3-carboxylic acid → HCID 58002611, compound

HRID 1642893Notes

Reaction equation

HRID 1642893 reaction equation
[CH:1]1([C:6]([N:8]2[CH2:13][CH:12]([C:14]3[CH:19]=[CH:18][C:17]([CH2:20][CH3:21])=[CH:16][CH:15]=3)[CH2:11][CH:10]([C:22](O)=O)[CH2:9]2)=[O:7])[CH2:5][CH2:4][CH2:3][CH2:2]1.[OH:25][N:26]=[C:27]([C:29]1[CH:33]=[C:32]([CH3:34])[O:31][N:30]=1)[NH2:28]>>[CH:1]1([C:6]([N:8]2[CH2:9][CH:10]([C:22]3[O:25][N:26]=[C:27]([C:29]4[CH:33]=[C:32]([CH3:34])[O:31][N:30]=4)[N:28]=3)[CH2:11][CH:12]([C:14]3[CH:19]=[CH:18][C:17]([CH2:20][CH3:21])=[CH:16][CH:15]=3)[CH2:13]2)=[O:7])[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 461646851-(Cyclopentylcarbonyl)-5-(4-ethylphenyl)piperidine-3-carboxylic acidHCID 136275400HCID 136275400, compound

Product 1

HCID 58002611HCID 58002611, compound

Procedure

66 mg (0.20 mmol) of 1-(cyclopentylcarbonyl)-5-(4-ethylphenyl)piperidine-3-carboxylic acid (Example 7A) and 31 mg (0.22 mmol, 1.1 eq.) of N′-hydroxy-5-methylisoxazole-3-carboximidamide were reacted according to the General Method 1. Yield: 50 mg (58% of theory)

Sources & evidence

ORD record
ord-91af04159f164bbda2f93086f76b2ddb
Source dataset
uspto-grants-2012_02
Patent number
US08119663B2

Reaction notes

Loading…