2-(4-Fluoro-phenyl)-N-hydroxy-acetamidine → HCID 58002151, compound

HRID 1642900Notes

Reaction equation

HRID 1642900 reaction equation
[N:1]1([C:7]([N:9]2[CH2:14][CH:13]([C:15]3[CH:20]=[CH:19][C:18]([O:21][C:22]([F:25])([F:24])[F:23])=[CH:17][CH:16]=3)[CH2:12][CH:11]([C:26](O)=[O:27])[CH2:10]2)=[O:8])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[F:29][C:30]1[CH:35]=[CH:34][C:33]([CH2:36][C:37](=[N:39]O)[NH2:38])=[CH:32][CH:31]=1>>[F:29][C:30]1[CH:31]=[CH:32][C:33]([CH2:36][C:37]2[N:38]=[C:26]([CH:11]3[CH2:12][CH:13]([C:15]4[CH:16]=[CH:17][C:18]([O:21][C:22]([F:24])([F:23])[F:25])=[CH:19][CH:20]=4)[CH2:14][N:9]([C:7]([N:1]4[CH2:6][CH2:5][O:4][CH2:3][CH2:2]4)=[O:8])[CH2:10]3)[O:27][N:39]=2)=[CH:34][CH:35]=1

Participants

3

Reactant 2

HCID 33078682-(4-Fluoro-phenyl)-N-hydroxy-acetamidineHCID 580025001-(Morpholin-4-ylcarbonyl)-5-[4-(trifluoromethoxy)phenyl]piperidine-3-carboxylic acid

Product 1

HCID 58002151HCID 58002151, compound

Procedure

80 mg (0.20 mmol) of 1-(morpholin-4-ylcarbonyl)-5-[4-(trifluoromethoxy)phenyl]piperidine-3-carboxylic acid (Example 44A) and 37 mg (0.22 mmol, 1.1 eq.) of 2-(4-fluorophenyl)-N′hydroxyethanimidamide were reacted according to the General Method 1. Yield: 61 mg (57% of theory)

Sources & evidence

ORD record
ord-42819dcd79324f4cad912ca0213c96bb
Source dataset
uspto-grants-2012_02
Patent number
US08119663B2

Reaction notes

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