Ethyl 2-amino-2-(hydroxyimino)acetate → HCID 58002273, compound

HRID 1642906Notes

Reaction equation

HRID 1642906 reaction equation
[CH:1]1([C:6]([N:8]2[CH2:13][CH:12]([C:14]3[CH:19]=[CH:18][C:17]([CH2:20][CH3:21])=[CH:16][CH:15]=3)[CH2:11][CH:10]([C:22](O)=O)[CH2:9]2)=[O:7])[CH2:5][CH2:4][CH2:3][CH2:2]1.[NH2:25][C:26](=[N:32][OH:33])[C:27]([O:29][CH2:30][CH3:31])=[O:28]>>[CH:1]1([C:6]([N:8]2[CH2:13][CH:12]([C:14]3[CH:19]=[CH:18][C:17]([CH2:20][CH3:21])=[CH:16][CH:15]=3)[CH2:11][CH:10]([C:22]3[O:33][N:32]=[C:26]([C:27]([O:29][CH2:30][CH3:31])=[O:28])[N:25]=3)[CH2:9]2)=[O:7])[CH2:2][CH2:3][CH2:4][CH2:5]1

Participants

3

Reactant 2

HCID 6785548Ethyl 2-amino-2-(hydroxyimino)acetateHCID 461646851-(Cyclopentylcarbonyl)-5-(4-ethylphenyl)piperidine-3-carboxylic acid

Product 1

HCID 58002273HCID 58002273, compound

Procedure

198 mg (0.60 mmol) of 1-(cyclopentylcarbonyl)-5-(4-ethylphenyl)piperidine-3-carboxylic acid (Example 7A) and 87 mg (0.66 mmol, 1.1 eq.) of ethyl 2-amino(hydroxyimino)ethanoate were reacted according to the General Method 1. Yield: 73 mg (27% of theory)

Sources & evidence

ORD record
ord-d4a25155c9224010bd3d6f87c29726e4
Source dataset
uspto-grants-2012_02
Patent number
US08119663B2

Reaction notes

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