HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-hydroxy-2-(4-morpholinyl)ethanimidamide → 4-[(5-[1-(Morpholin-4-ylcarbonyl)-5-[4-(trifluoromethoxy)phenyl]piperidin-3-yl]-1,2,4-oxadiazol-3-yl)methyl]morpholine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-hydroxy-2-(4-morpholinyl)ethanimidamide | HCID 53433451 | — |
| Reactant | 1-(Morpholin-4-ylcarbonyl)-5-[4-(trifluoromethoxy)phenyl]piperidine-3-carboxylic acid | HCID 58002500 | — |
| Product | 4-[(5-[1-(Morpholin-4-ylcarbonyl)-5-[4-(trifluoromethoxy)phenyl]piperidin-3-yl]-1,2,4-oxadiazol-3-yl)methyl]morpholine | HCID 58002210 | — |
Reaction Steps
80 mg (0.20 mmol) of 1-(morpholin-4-ylcarbonyl)-5-[4-(trifluoromethoxy)phenyl]piperidine-3-carboxylic acid (Example 44A) and 35 mg (0.22 mmol, 1.1 eq.) of N′-hydroxy-2-morpholin-4-ylethanimidamide were reacted according to the General Method 1. Yield: 28 mg (26% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08119663B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-969789c2a88f4b12be8452181bb3c6d0 |
| Source note | uspto-grants-2012_02 |