HuagongsheHuagongshe Chemistry Print Report · For research reference only
N'-Hydroxybenzenecarboximidamide → N-Ethyl-3-(4-ethylphenyl)-N-methyl-5-(3-phenyl-1,2,4-oxadiazol-5-yl)piperidine-1-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N'-Hydroxybenzenecarboximidamide | HCID 69186 | — |
| Reactant | 1-[Ethyl(methyl)carbamoyl]-5-(4-ethylphenyl)piperidine-3-carboxylic acid | HCID 58002321 | — |
| Product | N-Ethyl-3-(4-ethylphenyl)-N-methyl-5-(3-phenyl-1,2,4-oxadiazol-5-yl)piperidine-1-carboxamide | HCID 58002592 | — |
Reaction Steps
64 mg (0.20 mmol) of 1-[ethyl(methyl)carbamoyl]-5-(4-ethylphenyl)piperidine-3-carboxylic acid (Example 45A) and 30 mg (0.22 mmol, 1.1 eq.) of N′-hydroxybenzenecarboximidamide were reacted according to the General Method 1. Yield: 12 mg (14% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08119663B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-9c47a0aec2b146298e2f5ad5fc4d1199 |
| Source note | uspto-grants-2012_02 |