HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Fluoro-n-hydroxybenzimidamide → N-Ethyl-3-(4-ethylphenyl)-5-[3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl]-N-methylpiperidine-1-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Fluoro-n-hydroxybenzimidamide | HCID 593000 | — |
| Reactant | 1-[Ethyl(methyl)carbamoyl]-5-(4-ethylphenyl)piperidine-3-carboxylic acid | HCID 58002321 | — |
| Product | N-Ethyl-3-(4-ethylphenyl)-5-[3-(4-fluorophenyl)-1,2,4-oxadiazol-5-yl]-N-methylpiperidine-1-carboxamide | HCID 58002527 | — |
Reaction Steps
64 mg (0.20 mmol) of 1-[ethyl(methyl)carbamoyl]-5-(4-ethylphenyl)piperidine-3-carboxylic acid (Example 45A) and 34 mg (0.22 mmol, 1.1 eq.) of 4-fluoro-N′-hydroxybenzenecarboximidamide were reacted according to the General Method 1. Yield: 46 mg (52% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08119663B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-8263573079484339869f51955a770759 |
| Source note | uspto-grants-2012_02 |