HuagongsheHuagongshe Chemistry Print Report · For research reference only
n-Hydroxypivalimidamide → 3-(3-tert-Butyl-1,2,4-oxadiazol-5-yl)-N-ethyl-5-(4-ethylphenyl)-N-methylpiperidine-1-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | n-Hydroxypivalimidamide | HCID 2794841 | — |
| Reactant | 1-[Ethyl(methyl)carbamoyl]-5-(4-ethylphenyl)piperidine-3-carboxylic acid | HCID 58002321 | — |
| Product | 3-(3-tert-Butyl-1,2,4-oxadiazol-5-yl)-N-ethyl-5-(4-ethylphenyl)-N-methylpiperidine-1-carboxamide | HCID 58002353 | — |
Reaction Steps
64 mg (0.20 mmol) of 1-[ethyl(methyl)carbamoyl]-5-(4-ethylphenyl)piperidine-3-carboxylic acid (Example 45A) and 26 mg (0.22 mmol, 1.1 eq.) of N′-hydroxy-2,2-dimethylpropanimidamide were reacted according to the General Method 1. Yield: 52 mg (65% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08119663B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-02e0d11bf9384a8c9357d4b6caa56f0b |
| Source note | uspto-grants-2012_02 |