5-(4-Ethylphenyl)-1-(morpholin-4-ylcarbonyl)piperidine-3-carboxylic acid → HCID 58002472, compound

HRID 1642921Notes

Reaction equation

HRID 1642921 reaction equation
[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([CH:9]2[CH2:14][N:13]([C:15]([N:17]3[CH2:22][CH2:21][O:20][CH2:19][CH2:18]3)=[O:16])[CH2:12][CH:11]([C:23](O)=[O:24])[CH2:10]2)=[CH:5][CH:4]=1)[CH3:2].[F:26][C:27]1[S:31][C:30]([C:32](=[N:34]O)[NH2:33])=[CH:29][CH:28]=1>>[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([CH:9]2[CH2:10][CH:11]([C:23]3[O:24][N:34]=[C:32]([C:30]4[S:31][C:27]([F:26])=[CH:28][CH:29]=4)[N:33]=3)[CH2:12][N:13]([C:15]([N:17]3[CH2:18][CH2:19][O:20][CH2:21][CH2:22]3)=[O:16])[CH2:14]2)=[CH:5][CH:4]=1)[CH3:2]

Participants

3

Reactant 2

HCID 580022255-(4-Ethylphenyl)-1-(morpholin-4-ylcarbonyl)piperidine-3-carboxylic acidHCID 86636888HCID 86636888, compound

Product 1

HCID 58002472HCID 58002472, compound

Procedure

69 mg (0.20 mmol) of 5-(4-ethylphenyl)-1-(morpholin-4-ylcarbonyl)piperidine-3-carboxylic acid (Example 38A) and 35 mg (0.22 mmol, 1.1 eq.) of 5-fluoro-N′-hydroxythiophene-2-carboximidamide were reacted according to the General Method 1. Yield: 51 mg (54% of theory)

Sources & evidence

ORD record
ord-512ecc3236d440e8abc3f398ae2a5b17
Source dataset
uspto-grants-2012_02
Patent number
US08119663B2

Reaction notes

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