5-(4-Ethylphenyl)-1-(morpholin-4-ylcarbonyl)piperidine-3-carboxylic acid → HCID 58002136, compound

HRID 1642926Notes

Reaction equation

HRID 1642926 reaction equation
[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([CH:9]2[CH2:14][N:13]([C:15]([N:17]3[CH2:22][CH2:21][O:20][CH2:19][CH2:18]3)=[O:16])[CH2:12][CH:11]([C:23]([OH:25])=O)[CH2:10]2)=[CH:5][CH:4]=1)[CH3:2].[Cl:26][C:27]1[S:31][C:30]([C:32](=[N:34]O)[NH2:33])=[CH:29][CH:28]=1>>[Cl:26][C:27]1[S:31][C:30]([C:32]2[N:34]=[C:23]([CH:11]3[CH2:10][CH:9]([C:6]4[CH:5]=[CH:4][C:3]([CH2:1][CH3:2])=[CH:8][CH:7]=4)[CH2:14][N:13]([C:15]([N:17]4[CH2:18][CH2:19][O:20][CH2:21][CH2:22]4)=[O:16])[CH2:12]3)[O:25][N:33]=2)=[CH:29][CH:28]=1

Participants

3

Reactant 2

HCID 580022255-(4-Ethylphenyl)-1-(morpholin-4-ylcarbonyl)piperidine-3-carboxylic acidHCID 74860205HCID 74860205, compound

Product 1

HCID 58002136HCID 58002136, compound

Procedure

69 mg (0.20 mmol) of 5-(4-ethylphenyl)-1-(morpholin-4-ylcarbonyl)piperidine-3-carboxylic acid (Example 38A) and 39 mg (0.22 mmol, 1.1 eq.) of 5-chloro-N′-hydroxythiophene-2-carboximidamide were reacted according to the General Method 1. Yield: 60 mg (62% of theory)

Sources & evidence

ORD record
ord-6ecd47ccc1724b72820be41f91b44bbe
Source dataset
uspto-grants-2012_02
Patent number
US08119663B2

Reaction notes

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