HuagongsheHuagongshe Chemistry Print Report · For research reference only
N'-Hydroxybenzenecarboximidamide → 3-(4-Ethylphenyl)-5-(3-phenyl-1,2,4-oxadiazol-5-yl)-1-(pyrrolidin-1-ylcarbonyl)piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N'-Hydroxybenzenecarboximidamide | HCID 69186 | — |
| Reactant | 5-(4-Ethylphenyl)-1-(pyrrolidin-1-ylcarbonyl)piperidine-3-carboxylic acid | HCID 58002207 | — |
| Product | 3-(4-Ethylphenyl)-5-(3-phenyl-1,2,4-oxadiazol-5-yl)-1-(pyrrolidin-1-ylcarbonyl)piperidine | HCID 58002718 | — |
Reaction Steps
73 mg (0.22 mmol) of 5-(4-ethylphenyl)-1-(pyrrolidin-1-ylcarbonyl)piperidine-3-carboxylic acid (Example 41A) and 33 mg (0.24 mmol, 1.1 eq.) of N′-hydroxybenzenecarboximidamide were reacted according to the General Method 1. Yield: 32 mg (33% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08119663B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-0926dfd015c5415db7f4d9d2556b5278 |
| Source note | uspto-grants-2012_02 |