HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-fluoro-N'-hydroxybenzene-1-carboximidamide → 3-(4-Ethylphenyl)-5-[3-(2-fluorophenyl)-1,2,4-oxadiazol-5-yl]-1-(pyrrolidin-1-ylcarbonyl)piperidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-fluoro-N'-hydroxybenzene-1-carboximidamide | HCID 3259589 | — |
| Reactant | 5-(4-Ethylphenyl)-1-(pyrrolidin-1-ylcarbonyl)piperidine-3-carboxylic acid | HCID 58002207 | — |
| Product | 3-(4-Ethylphenyl)-5-[3-(2-fluorophenyl)-1,2,4-oxadiazol-5-yl]-1-(pyrrolidin-1-ylcarbonyl)piperidine | HCID 58002441 | — |
Reaction Steps
73 mg (0.22 mmol) of 5-(4-ethylphenyl)-1-(pyrrolidin-1-ylcarbonyl)piperidine-3-carboxylic acid (Example 41A) and 47 mg (0.24 mmol, 1.1 eq.) of 2-fluoro-N′-hydroxybenzenecarboximidamide were reacted according to the General Method 1. Yield: 46 mg (47% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08119663B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-ff9694b5d1ae4cda8dba16bb2aad22fd |
| Source note | uspto-grants-2012_02 |