HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromo-1-(6-methylpyridin-3-yl)ethanone → 4-({3-[4-(6-Methylpyridin-3-yl)-1,3-thiazol-2-yl]-5-[4-(trifluoromethyl)phenyl]piperidin-1-yl}-carbonyl)morpholine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromo-1-(6-methylpyridin-3-yl)ethanone | HCID 45480512 | — |
| Reactant | 1-(Morpholin-4-ylcarbonyl)-5-[4-(trifluoromethyl)phenyl]piperidine-3-carbothioamide | HCID 58002319 | — |
| Product | 4-({3-[4-(6-Methylpyridin-3-yl)-1,3-thiazol-2-yl]-5-[4-(trifluoromethyl)phenyl]piperidin-1-yl}-carbonyl)morpholine | HCID 58002515 | — |
Reaction Steps
100 mg (0.224 mmol) of 1-(morpholin-4-ylcarbonyl)-5-[4-(trifluoromethyl)phenyl]piperidine-3-carbothioamide (Example 53A) and 58 mg (0.269 mmol) of 2-bromo-1-(6-methylpyridin-3-yl)ethanone were reacted according to the General Method 3. Yield: 18 mg (15% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08119663B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-0e63eeb3e5fc4cd49fe2fff39aa9ab60 |
| Source note | uspto-grants-2012_02 |