HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromoacetamidopyridine → 4-({3-(4-Pyridin-2-yl-1,3-thiazol-2-yl)-5-[4-(trifluoromethyl)phenyl]piperidin-1-yl}carbonyl)-morpholine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromoacetamidopyridine | HCID 38384 | — |
| Reactant | 1-(Morpholin-4-ylcarbonyl)-5-[4-(trifluoromethyl)phenyl]piperidine-3-carbothioamide | HCID 58002319 | — |
| Product | 4-({3-(4-Pyridin-2-yl-1,3-thiazol-2-yl)-5-[4-(trifluoromethyl)phenyl]piperidin-1-yl}carbonyl)-morpholine | HCID 58002627 | — |
Reaction Steps
100 mg (0.224 mmol) of 1-(morpholin-4-ylcarbonyl)-5-[4-(trifluoromethyl)phenyl]piperidine-3-carbothioamide (Example 53A) and 76 mg (0.269 mmol) of 2-bromo-1-pyridin-2-ylethanone were reacted according to the General Method 3. Yield: 8 mg (7% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08119663B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-c729337b480a4c47a3ee0155aa580739 |
| Source note | uspto-grants-2012_02 |