HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromo-1-(6-chloropyridin-3-YL)ethanone → 4-({3-[4-(6-Chloropyridin-3-yl)-1,3-thiazol-2-yl]-5-[4-(trifluoromethyl)phenyl]piperidin-1-yl}carbonyl)morpholine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromo-1-(6-chloropyridin-3-YL)ethanone | HCID 19432921 | — |
| Reactant | 1-(Morpholin-4-ylcarbonyl)-5-[4-(trifluoromethyl)phenyl]piperidine-3-carbothioamide | HCID 58002319 | — |
| Product | 4-({3-[4-(6-Chloropyridin-3-yl)-1,3-thiazol-2-yl]-5-[4-(trifluoromethyl)phenyl]piperidin-1-yl}carbonyl)morpholine | HCID 58002484 | — |
Reaction Steps
100 mg (0.224 mmol) of 1-(morpholin-4-ylcarbonyl)-5-[4-(trifluoromethyl)phenyl]piperidine-3-carbothioamide (Example 53A) and 85 mg (0.269 mmol) of 2-bromo-1-(6-chloropyridin-3-yl)ethanone were reacted according to the General Method 3. Yield: 17 mg (14% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08119663B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-e90307162366496a97df9e39fc3a2f26 |
| Source note | uspto-grants-2012_02 |