2-Bromo-1-(2,4-dichlorophenyl)ethan-1-one → HCID 58002357, compound

HRID 1642938Notes

Reaction equation

HRID 1642938 reaction equation
[N:1]1([C:7]([N:9]2[CH2:14][CH:13]([C:15]3[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][CH:16]=3)[CH2:12][CH:11]([C:25](=[S:27])[NH2:26])[CH2:10]2)=[O:8])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.Br[CH2:29][C:30]([C:32]1[CH:37]=[CH:36][C:35]([Cl:38])=[CH:34][C:33]=1[Cl:39])=O>>[Cl:39][C:33]1[CH:34]=[C:35]([Cl:38])[CH:36]=[CH:37][C:32]=1[C:30]1[N:26]=[C:25]([CH:11]2[CH2:12][CH:13]([C:15]3[CH:20]=[CH:19][C:18]([C:21]([F:22])([F:23])[F:24])=[CH:17][CH:16]=3)[CH2:14][N:9]([C:7]([N:1]3[CH2:6][CH2:5][O:4][CH2:3][CH2:2]3)=[O:8])[CH2:10]2)[S:27][CH:29]=1

Participants

3

Reactant 2

HCID 758282-Bromo-1-(2,4-dichlorophenyl)ethan-1-oneHCID 580023191-(Morpholin-4-ylcarbonyl)-5-[4-(trifluoromethyl)phenyl]piperidine-3-carbothioamide

Product 1

HCID 58002357HCID 58002357, compound

Procedure

100 mg (0.224 mmol) of 1-(morpholin-4-ylcarbonyl)-5-[4-(trifluoromethyl)phenyl]piperidine-3-carbothioamide (Example 53A) and 72 mg (0.269 mmol) of 2-bromo-1-(2,4-dichlorophenyl)ethanone were reacted according to the General Method 3. Yield: 43 mg (34% of theory)

Sources & evidence

ORD record
ord-11f14da3bc504d1c8297e049c3d812fa
Source dataset
uspto-grants-2012_02
Patent number
US08119663B2

Reaction notes

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