3-fluoro-N'-hydroxybenzene-1-carboximidamide → {3-[3-(3-Fluorophenyl)-1,2,4-oxadiazol-5-yl]-5-[4-(trifluoromethoxy)phenyl]piperidin-1-yl}(4-hydroxypiperidin-1-yl)methanone

Participants

Reaction Steps

60 mg (0.14 mmol) of 1-[(4-hydroxypiperidin-1-yl)carbonyl]-5-[4-(trifluoromethoxy)phenyl]piperidine-3-carboxylic acid (Example 63A) and 35 mg (0.22 mmol, 1.5 eq.) of 3-fluoro-N′-hydroxybenzenecarboximidamide were reatced according to the General Method 2. Yield: 35 mg (45% of theory)

Provenance & Evidence