N'-Hydroxy-2-pyrazinecarboximidamide → (4-Hydroxypiperidin-1-yl) {3-[3-(pyrazin-2-yl)-1,2,4-oxadiazol-5-yl]-5-[4-(trifluoromethoxy)-phenyl]piperidin-1-yl}methanone

Participants

Reaction Steps

100 mg (0.24 mmol) of 1-[(4-hydroxypiperidin-1-yl)carbonyl]-5-[4-(trifluoromethoxy)phenyl]piperidine-3-carboxylic acid (Example 63A) and 50 mg (0.36 mmol, 1.5 eq.) of N′-hydroxypyrazine-2-carboximidamide were reacted according to the General Method 2. Yield: 34 mg (27% of theory)

Provenance & Evidence