5-(4-Ethylphenyl)-1-[(4-hydroxypiperidin-1-yl)carbonyl]piperidine-3-carboxylic acid → [3-(4-Ethylphenyl)-5-(3-phenyl-1,2,4-oxadiazol-5-yl)piperidin-1-yl] (4-hydroxypiperidin-1-yl)methanone

Participants

Reaction Steps

80 mg (0.22 mmol) of 5-(4-ethylphenyl)-1-[(4-hydroxypiperidin-1-yl)carbonyl]piperidine-3-carboxylic acid (Example 59A) and 45 mg (0.33 mmol, 1.5 eq.) of 1-hydroxybenzene-carboximidamide were reacted according to the General Method 2. Yield: 76 mg (74% of theory)

Provenance & Evidence