N'-Hydroxy-2-pyrazinecarboximidamide → {3-(4-Ethylphenyl)-5-[3-(pyrazin-2-yl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl}(4-hydroxypiperidin-1-yl)methanone

Participants

Reaction Steps

80 mg (0.22 mmol) of 5-(4-ethylphenyl)-1-[(4-hydroxypiperidin-1-yl)carbonyl]piperidine-3-carboxylic acid (Example 59A) and 46 mg (0.33 mmol, 1.5 eq.) of N′-hydroxypyrazine-2-carboximidamide were reacted according to the General Method 2. Yield: 24 mg (23% of theory)

Provenance & Evidence