3-fluoro-N'-hydroxybenzene-1-carboximidamide → 1-({3-(4-Ethylphenyl)-5-[3-(3-fluorophenyl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl}carbonyl)-piperidine-4-carbonitrile

Participants

Reaction Steps

80 mg (0.22 mmol) of 5-(4-ethylphenyl)-1-[(4-cyanopiperidin-1-yl)carbonyl]piperidine-3-carboxylic acid (Example 60A) and 50 mg (0.33 mmol, 1.5 eq.) of 3-fluoro-N′-hydroxybenzenecarboximidamide were reacted according to the General Method 2. Yield: 81 mg (77% of theory)

Provenance & Evidence