HCID 2763396, compound → HCID 58002530, compound

HRID 1642960Notes

Reaction equation

HRID 1642960 reaction equation
[N:1]1([C:7]([N:9]2[CH2:14][CH:13]([C:15]3[CH:20]=[CH:19][C:18]([C:21]([F:24])([F:23])[F:22])=[CH:17][CH:16]=3)[CH2:12][CH:11]([C:25]([OH:27])=O)[CH2:10]2)=[O:8])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.O[N:29]=[C:30]([NH2:36])[CH2:31][S:32]([CH3:35])(=[O:34])=[O:33]>>[CH3:35][S:32]([CH2:31][C:30]1[N:36]=[C:25]([CH:11]2[CH2:12][CH:13]([C:15]3[CH:16]=[CH:17][C:18]([C:21]([F:24])([F:22])[F:23])=[CH:19][CH:20]=3)[CH2:14][N:9]([C:7]([N:1]3[CH2:6][CH2:5][O:4][CH2:3][CH2:2]3)=[O:8])[CH2:10]2)[O:27][N:29]=1)(=[O:34])=[O:33]

Participants

3

Reactant 2

HCID 2763396HCID 2763396, compoundHCID 580024471-(Morpholin-4-ylcarbonyl)-5-[4-(trifluoromethyl)phenyl]piperidine-3-carboxylic acid

Product 1

HCID 58002530HCID 58002530, compound

Procedure

250 mg (about 0.65 mmol) of 1-(morpholin-4-ylcarbonyl)-5-[4-(trifluoromethyl)phenyl]piperidine-3-carboxylic acid and 108 mg (0.71 mmol) of N′-hydroxy-2-(methylsulphonyl)ethanimidamide were reacted according to the General Method 1. Yield: 5 mg (2% of theory)

Sources & evidence

ORD record
ord-7101213c03304bd2b7496e61af64337f
Source dataset
uspto-grants-2012_02
Patent number
US08119663B2

Reaction notes

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