4,4-Difluoropiperidine hydrochloride → HCID 58002649, compound

HRID 1642962Notes

Reaction equation

HRID 1642962 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:8]2[N:12]=[C:11]([CH:13]3[CH2:18][CH:17]([C:19]4[CH:24]=[CH:23][C:22]([O:25][C:26]([F:29])([F:28])[F:27])=[CH:21][CH:20]=4)[CH2:16][N:15]([C:30](Cl)=[O:31])[CH2:14]3)[O:10][N:9]=2)[CH:5]=[CH:6][CH:7]=1.Cl.[F:34][C:35]1([F:41])[CH2:40][CH2:39][NH:38][CH2:37][CH2:36]1>>[F:34][C:35]1([F:41])[CH2:40][CH2:39][N:38]([C:30]([N:15]2[CH2:16][CH:17]([C:19]3[CH:24]=[CH:23][C:22]([O:25][C:26]([F:29])([F:28])[F:27])=[CH:21][CH:20]=3)[CH2:18][CH:13]([C:11]3[O:10][N:9]=[C:8]([C:4]4[CH:5]=[CH:6][CH:7]=[C:2]([F:1])[CH:3]=4)[N:12]=3)[CH2:14]2)=[O:31])[CH2:37][CH2:36]1

Participants

3

Reactant 2

HCID 27583514,4-Difluoropiperidine hydrochlorideHCID 58002127HCID 58002127, compound

Product 1

HCID 58002649HCID 58002649, compound

Procedure

100 mg (0.21 mmol) of the compound from Example 179A and 33 mg (0.2 mmol) of 4,4-difluoropiperidine hydrochloride were reacted according to the General Method 5. Yield: 37 mg (30% of theory)

Sources & evidence

ORD record
ord-c09e56a4fa33407095443dfa757a605b
Source dataset
uspto-grants-2012_02
Patent number
US08119663B2

Reaction notes

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