HuagongsheHuagongshe Chemistry Print Report · For research reference only
N'-Hydroxycyclopropanecarboximidamide → [3-(3-Cyclopropyl-1,2,4-oxadiazol-5-yl)-5-(4-ethylphenyl)piperidin-1-yl] (3-hydroxyazetidin-1-yl)methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N'-Hydroxycyclopropanecarboximidamide | HCID 2794666 | — |
| Reactant | 5-(4-Ethylphenyl)-1-[(3-hydroxyazetidin-1-yl)carbonyl]piperidine-3-carboxylic acid | HCID 58002369 | — |
| Product | [3-(3-Cyclopropyl-1,2,4-oxadiazol-5-yl)-5-(4-ethylphenyl)piperidin-1-yl] (3-hydroxyazetidin-1-yl)methanone | HCID 58002631 | — |
Reaction Steps
60 mg (0.18 mmol) of the compound from Example 138A and 27 mg (0.27 mmol) of N′-hydroxycyclopropanecarboximidamide were reacted according to the General Method 2. Yield: 24 mg (33% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08119663B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-54e8289895f44bf583a8f5822ef308b5 |
| Source note | uspto-grants-2012_02 |