HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,6-difluoro-N'-hydroxybenzenecarboximidamide → 1-{[3-[3-(2,6-Difluorophenyl)-1,2,4-oxadiazol-5-yl]-5-(4-ethylphenyl)piperidin-1-yl]carbonyl}-piperidine-4-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,6-difluoro-N'-hydroxybenzenecarboximidamide | HCID 3492978 | — |
| Reactant | 5-(4-Ethylphenyl)-1-[(4-cyanopiperidin-1-yl)carbonyl]piperidine-3-carboxylic acid | HCID 58002424 | — |
| Product | 1-{[3-[3-(2,6-Difluorophenyl)-1,2,4-oxadiazol-5-yl]-5-(4-ethylphenyl)piperidin-1-yl]carbonyl}-piperidine-4-carbonitrile | HCID 58002707 | — |
Reaction Steps
60 mg (0.16 mmol) of the compound from Example 60A and 42 mg (0.24 mmol) of 2,6-difluoro-N′-hydroxybenzenecarboximidamide were reacted according to the General Method 2. Yield: 53 mg (65% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08119663B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-5e28868db0324681aff819ce76fe9bd7 |
| Source note | uspto-grants-2012_02 |