N'-Hydroxycyclopropanecarboximidamide → HCID 58002531, compound

HRID 1642968Notes

Reaction equation

HRID 1642968 reaction equation
[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([CH:9]2[CH2:14][N:13]([C:15]([N:17]3[CH2:22][CH2:21][O:20][CH2:19][CH2:18]3)=[O:16])[CH2:12][CH:11]([C:23]([OH:25])=O)[CH2:10]2)=[CH:5][CH:4]=1)[CH3:2].O[N:27]=[C:28]([CH:30]1[CH2:32][CH2:31]1)[NH2:29]>>[CH:30]1([C:28]2[N:29]=[C:23]([CH:11]3[CH2:10][CH:9]([C:6]4[CH:5]=[CH:4][C:3]([CH2:1][CH3:2])=[CH:8][CH:7]=4)[CH2:14][N:13]([C:15]([N:17]4[CH2:22][CH2:21][O:20][CH2:19][CH2:18]4)=[O:16])[CH2:12]3)[O:25][N:27]=2)[CH2:32][CH2:31]1

Participants

3

Reactant 2

HCID 2794666N'-HydroxycyclopropanecarboximidamideHCID 580022255-(4-Ethylphenyl)-1-(morpholin-4-ylcarbonyl)piperidine-3-carboxylic acid

Product 1

HCID 58002531HCID 58002531, compound

Procedure

60 mg (0.17 mmol) of the compound from Example 38A and 27 mg (0.26 mmol) of N′-hydroxycyclopropanecarboximidamide were reacted according to the General Method 2. Yield: 51 mg (70% of theory)

Sources & evidence

ORD record
ord-c8248b744fff4b108b7ef052e1a60bf0
Source dataset
uspto-grants-2012_02
Patent number
US08119663B2

Reaction notes

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