2,6-difluoro-N'-hydroxybenzenecarboximidamide → {3-[3-(2,6-Difluorophenyl)-1,2,4-oxadiazol-5-yl]-5-(4-ethylphenyl)piperidin-1-yl}(4-hydroxy-piperidin-1-yl)methanone

Participants

Reaction Steps

80 mg (0.22 mmol) of 5-(4-ethylphenyl)-1-[(4-hydroxypiperidin-1-yl)carbonyl]piperidine-3-carboxylic acid (Example 59A) and 57 mg (0.33 mmol) of 2,6-difluoro-N′-hydroxybenzenecarboximidamide were reacted according to the General Method 2. Yield: 57 mg (52% of theory)

Provenance & Evidence