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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1642979Generated: October 31, 2026

4,4-Difluoropiperidine hydrochloride → HCID 58002734, compound

https://huagongshe.com/reaction/1642979

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4,4-Difluoropiperidine hydrochlorideHCID 2758351—
Reactant4-Nitrophenyl 3-(3-cyclopropyl-1,2,4-oxadiazol-5-yl)-5-[4-(trifluoromethoxy)phenyl]piperidine-1-carboxylateHCID 58002632—
ProductHCID 58002734HCID 58002734—

Reaction Steps

100 mg (0.19 mmol) of the compound from Example 176A and 91 mg (0.58 mmol) of 4,4-difluoropiperidine hydrochloride were reacted according to the General Method 6. Yield: 48 mg (50% of theory)

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08119663B2
Source datasetuspto-grants-2012_02
ORD IDord-fcbb36bcc81e450eb5c54241f1641a1e
Source noteuspto-grants-2012_02