4-Hydroxypyrrolidine → HCID 58002716, compound

HRID 1642981Notes

Reaction equation

[F:1][C:2]1[CH:3]=[C:4]([C:8]2[N:12]=[C:11]([CH:13]3[CH2:18][CH:17]([C:19]4[CH:24]=[CH:23][C:22]([C:25]([F:28])([F:27])[F:26])=[CH:21][CH:20]=4)[CH2:16][N:15]([C:29](OC4C=CC([N+]([O-])=O)=CC=4)=[O:30])[CH2:14]3)[O:10][N:9]=2)[CH:5]=[CH:6][CH:7]=1.[NH:41]1[CH2:45][CH2:44][CH:43]([OH:46])[CH2:42]1>>[F:1][C:2]1[CH:3]=[C:4]([C:8]2[N:12]=[C:11]([CH:13]3[CH2:18][CH:17]([C:19]4[CH:20]=[CH:21][C:22]([C:25]([F:27])([F:26])[F:28])=[CH:23][CH:24]=4)[CH2:16][N:15]([C:29]([N:41]4[CH2:45][CH2:44][CH:43]([OH:46])[CH2:42]4)=[O:30])[CH2:14]3)[O:10][N:9]=2)[CH:5]=[CH:6][CH:7]=1

Participants

Reactant 2

HCID 982104-Hydroxypyrrolidine

HCID 58002651HCID 58002651, compound

Product 1

HCID 58002716HCID 58002716, compound

Procedure

100 mg (0.18 mmol) of the compound from Example 187A and 47 mg (0.54 mmol) of 3-pyrrolidinol were reacted according to the General Method 6. Yield: 25 mg (26% of theory)

Sources & evidence

ORD record: ord-d9a15cab151c45b0a8e2f5735a41653b
Source dataset: uspto-grants-2012_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08119663B2

Reaction notes

Loading…