1-[(4-Cyanopiperidin-1-yl)carbonyl]-5-[4-(trifluoromethyl)phenyl]piperidine-3-carboxylic acid → 1-({3-(3-{[1-(Hydroxymethyl)cyclopropyl]methyl}-1,2,4-oxadiazol-5-yl)-5-[4-(trifluoromethyl)-phenyl]piperidin-1-yl}carbonyl)piperidine-4-carbonitrile

Participants

Role	Name	HCID	Charge
Reactant	1-[(4-Cyanopiperidin-1-yl)carbonyl]-5-[4-(trifluoromethyl)phenyl]piperidine-3-carboxylic acid	HCID 58002332	—
Reactant	N'-Hydroxy-2-[1-(hydroxymethyl)cyclopropyl]ethanimidamide	HCID 79009133	—
Product	1-({3-(3-{[1-(Hydroxymethyl)cyclopropyl]methyl}-1,2,4-oxadiazol-5-yl)-5-[4-(trifluoromethyl)-phenyl]piperidin-1-yl}carbonyl)piperidine-4-carbonitrile	HCID 58002440	—

Reaction Steps

100 mg (0.24 mmol) of the compound from Example 100A and 61 mg (0.37 mmol) of the compound from Example 67A were reacted according to the General Method 2. Yield: 70 mg (56% of theory)

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08119663B2
Source dataset	uspto-grants-2012_02
ORD ID	ord-da82d13f5a53404e92dff825627f7aa2
Source note	uspto-grants-2012_02