N'-Hydroxy-2-methylpropanimidamide → HCID 58002724, compound

HRID 1642988Notes

Reaction equation

HRID 1642988 reaction equation
[C:1]([CH:3]1[CH2:8][CH2:7][N:6]([C:9]([N:11]2[CH2:16][CH:15]([C:17]3[CH:22]=[CH:21][C:20]([CH3:23])=[C:19]([CH3:24])[CH:18]=3)[CH2:14][CH:13]([C:25](O)=[O:26])[CH2:12]2)=[O:10])[CH2:5][CH2:4]1)#[N:2].O[N:29]=[C:30]([NH2:34])[CH:31]([CH3:33])[CH3:32]>>[CH3:24][C:19]1[CH:18]=[C:17]([CH:15]2[CH2:14][CH:13]([C:25]3[O:26][N:34]=[C:30]([CH:31]([CH3:33])[CH3:32])[N:29]=3)[CH2:12][N:11]([C:9]([N:6]3[CH2:5][CH2:4][CH:3]([C:1]#[N:2])[CH2:8][CH2:7]3)=[O:10])[CH2:16]2)[CH:22]=[CH:21][C:20]=1[CH3:23]

Participants

3

Reactant 2

HCID 2794833N'-Hydroxy-2-methylpropanimidamideHCID 58002563HCID 58002563, compound

Product 1

HCID 58002724HCID 58002724, compound

Procedure

80 mg (0.210 mmol) of the compound from Example 132A and 33 mg (0.315 mmol) of N′-hydroxy-2-methylpropanimidamide were reacted according to the General Method 2. Yield: 47 mg (51% of theory)

Sources & evidence

ORD record
ord-a1136c0f7a644d7a9a6848473526fd96
Source dataset
uspto-grants-2012_02
Patent number
US08119663B2

Reaction notes

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