HuagongsheHuagongshe Chemistry Print Report · For research reference only
N'-Hydroxycyclopropanecarboximidamide → {3-(3-Cyclopropyl-1,2,4-oxadiazol-5-yl)-5-[3-(trifluoromethoxy)phenyl]piperidin-1-yl}(4-hydroxypiperidin-1-yl)methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N'-Hydroxycyclopropanecarboximidamide | HCID 2794666 | — |
| Reactant | 1-[(4-Hydroxypiperidin-1-yl)carbonyl]-5-[3-(trifluoromethoxy)phenyl]piperidine-3-carboxylic acid | HCID 58002193 | — |
| Product | {3-(3-Cyclopropyl-1,2,4-oxadiazol-5-yl)-5-[3-(trifluoromethoxy)phenyl]piperidin-1-yl}(4-hydroxypiperidin-1-yl)methanone | HCID 58002247 | — |
Reaction Steps
60 mg (0.14 mmol) of the compound from Example 194A and 22 mg (0.22 mmol) of N′-hydroxycyclopropanecarboximidamide were reacted according to the General Method 2. Yield: 45 mg (64% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08119663B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-e093fe6e07ce4b59bc56b4833c9d4173 |
| Source note | uspto-grants-2012_02 |