4-Hydroxypyrrolidine → HCID 58002571, compound

HRID 1642994Notes

Reaction equation

HRID 1642994 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:8]2[N:12]=[C:11]([CH:13]3[CH2:18][CH:17]([C:19]4[CH:24]=[CH:23][C:22]([O:25][C:26]([F:29])([F:28])[F:27])=[CH:21][CH:20]=4)[CH2:16][N:15]([C:30](Cl)=[O:31])[CH2:14]3)[O:10][N:9]=2)[CH:5]=[CH:6][CH:7]=1.[NH:33]1[CH2:37][CH2:36][CH:35]([OH:38])[CH2:34]1>>[F:1][C:2]1[CH:3]=[C:4]([C:8]2[N:12]=[C:11]([CH:13]3[CH2:18][CH:17]([C:19]4[CH:24]=[CH:23][C:22]([O:25][C:26]([F:29])([F:28])[F:27])=[CH:21][CH:20]=4)[CH2:16][N:15]([C:30]([N:33]4[CH2:37][CH2:36][CH:35]([OH:38])[CH2:34]4)=[O:31])[CH2:14]3)[O:10][N:9]=2)[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 982104-HydroxypyrrolidineHCID 58002127HCID 58002127, compound

Product 1

HCID 58002571HCID 58002571, compound

Procedure

100 mg (0.21 mmol) of the compound from Example 179A and 19 mg (0.21 mmol) of 3-pyrrolidinol were reacted according to the General Method 5. Yield: 43 mg (39% of theory)

Sources & evidence

ORD record
ord-e26ec5a6943848db82733a3d47b61836
Source dataset
uspto-grants-2012_02
Patent number
US08119663B2

Reaction notes

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