N'-Hydroxy-2-pyrazinecarboximidamide → 1-({3-[3-(Pyrazin-2-yl)-1,2,4-oxadiazol-5-yl]-5-[4-(trifluoromethoxy)phenyl]piperidin-1-yl}-carbonyl)piperidine-4-carbonitrile

Participants

Reaction Steps

100 mg (0.24 mmol) of 1-[(4-cyanopiperidin-1-yl)carbonyl]-5-[4-(trifluoromethoxy)phenyl]piperidine-3-carboxylic acid (Example 108A) and 49 mg (0.35 mmol) of N′-hydroxypyrazine-2-carboximidamide were reacted according to the General Method 2. Yield: 69 mg (56% of theory).

Provenance & Evidence