1-[(4-Cyanopiperidin-1-yl)carbonyl]-5-[4-(trifluoromethyl)phenyl]piperidine-3-carboxylic acid → 1-({3-[3-(2-Hydroxy-2-methylpropyl)-1,2,4-oxadiazol-5-yl]-5-[4-(trifluoromethyl)phenyl]-piperidin-1-yl}carbonyl)piperidine-4-carbonitrile

Participants

Reaction Steps

80 mg (0.188 mmol) of the compound from Example 100A and 52 mg (0.281 mmol) of N′,3-dihydroxy-3-methylbutanimidamide were reacted according to the General Method 2. Yield: 65 mg (67% of theory)

Provenance & Evidence