(1E)-N'-Hydroxy-3-methoxypropanimidamide hydrochloride → (4-Hydroxypiperidin-1-yl){3-[3-(2-methoxyethyl)-1,2,4-oxadiazol-5-yl]-5-[3-(trifluoromethoxy)-phenyl]piperidin-1-yl}methanone

Participants

Role	Name	HCID	Charge
Reactant	(1E)-N'-Hydroxy-3-methoxypropanimidamide hydrochloride	HCID 4390391	—
Reactant	1-[(4-Hydroxypiperidin-1-yl)carbonyl]-5-[3-(trifluoromethoxy)phenyl]piperidine-3-carboxylic acid	HCID 58002193	—
Product	(4-Hydroxypiperidin-1-yl){3-[3-(2-methoxyethyl)-1,2,4-oxadiazol-5-yl]-5-[3-(trifluoromethoxy)-phenyl]piperidin-1-yl}methanone	HCID 58002300	—

Reaction Steps

200 mg (0.48 mmol) of the compound from Example 194A and 113 mg (0.72 mmol) of N′-hydroxy-3-methoxypropanimidamide were reacted according to the General Method 2. Yield: 182 mg (73% of theory)

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08119663B2
Source dataset	uspto-grants-2012_02
ORD ID	ord-14d489955e7b4dc9925739d6e18e67fa
Source note	uspto-grants-2012_02