N'-hydroxy-3-(trifluoromethyl)benzimidamide → HCID 58002155, compound

HRID 1643006Notes

Reaction equation

HRID 1643006 reaction equation
[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][C:8]([CH:11]2[CH2:16][N:15]([C:17]([N:19]3[CH2:24][CH2:23][O:22][CH2:21][CH2:20]3)=[O:18])[CH2:14][CH:13]([C:25](O)=[O:26])[CH2:12]2)=[CH:7][CH:6]=1)(=[O:4])=[O:3].O[N:29]=[C:30]([C:32]1[CH:37]=[CH:36][CH:35]=[C:34]([C:38]([F:41])([F:40])[F:39])[CH:33]=1)[NH2:31]>>[CH3:1][S:2]([C:5]1[CH:10]=[CH:9][C:8]([CH:11]2[CH2:12][CH:13]([C:25]3[O:26][N:31]=[C:30]([C:32]4[CH:37]=[CH:36][CH:35]=[C:34]([C:38]([F:39])([F:40])[F:41])[CH:33]=4)[N:29]=3)[CH2:14][N:15]([C:17]([N:19]3[CH2:24][CH2:23][O:22][CH2:21][CH2:20]3)=[O:18])[CH2:16]2)=[CH:7][CH:6]=1)(=[O:3])=[O:4]

Participants

3

Reactant 2

HCID 609330N'-hydroxy-3-(trifluoromethyl)benzimidamideHCID 58002581HCID 58002581, compound

Product 1

HCID 58002155HCID 58002155, compound

Procedure

60 mg (0.15 mmol) of the compound from Example 198A and 46 mg (0.23 mmol) of N′-hydroxy-3-(trifluoromethyl)benzenecarboximidamide were reacted according to the General Method 2. Yield: 61 mg (69% of theory)

Sources & evidence

ORD record
ord-eb7384297a4148ddabbbc6acf34aad12
Source dataset
uspto-grants-2012_02
Patent number
US08119663B2

Reaction notes

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