HuagongsheHuagongshe Chemistry Print Report · For research reference only
N'-Hydroxy-2-pyrazinecarboximidamide → (4-Hydroxypiperidin-1-yl) {3-[3-(pyrazin-2-yl)-1,2,4-oxadiazol-5-yl]-5-[3-(trifluoromethoxy)-phenyl]piperidin-1-yl}methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N'-Hydroxy-2-pyrazinecarboximidamide | HCID 2737233 | — |
| Reactant | 1-[(4-Hydroxypiperidin-1-yl)carbonyl]-5-[3-(trifluoromethoxy)phenyl]piperidine-3-carboxylic acid | HCID 58002193 | — |
| Product | (4-Hydroxypiperidin-1-yl) {3-[3-(pyrazin-2-yl)-1,2,4-oxadiazol-5-yl]-5-[3-(trifluoromethoxy)-phenyl]piperidin-1-yl}methanone | HCID 58002684 | — |
Reaction Steps
60 mg (0.14 mmol) of the compound from Example 194A and 30 mg (0.22 mmol) of N′-hydroxypyrazin-2-carboximidamide were reacted according to the General Method 2. Yield: 36 mg (48% of theory)
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08119663B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-ae5b192a5e8e4d419747e14e23e5e8ed |
| Source note | uspto-grants-2012_02 |