Trifluoroacetic acid → HCID 58002585, compound

Participants

Reaction Steps

110 mg (0.186 mmol) of the compound from Example 188A were initially charged in 1.4 ml of dichloromethane, and 143 μl (212 mg, 1.87 mmol) of trifluoroacetic acid were added. The reaction mixture was stirred at RT for 12 h, and then taken up in ethyl acetate and washed with saturated aqueous sodium bicarbonate solution and saturated aqueous sodium chloride solution. The organic phase was dried over sodium sulphate, filtered and concentrated under reduced pressure. The crude product was purified by preparative HPLC. Yield: 48 mg (53% of theory)

Provenance & Evidence