N'-Hydroxycyclopropanecarboximidamide → HCID 58002657, compound

HRID 1643016Notes

Reaction equation

[OH:1][CH:2]1[CH2:7][CH2:6][N:5]([C:8]([N:10]2[CH2:15][CH:14]([C:16]3[CH:21]=[CH:20][C:19]([O:22][C:23]([F:26])([F:25])[F:24])=[C:18]([CH3:27])[CH:17]=3)[CH2:13][CH:12]([C:28]([OH:30])=O)[CH2:11]2)=[O:9])[CH2:4][CH2:3]1.O[N:32]=[C:33]([CH:35]1[CH2:37][CH2:36]1)[NH2:34]>>[CH:35]1([C:33]2[N:34]=[C:28]([CH:12]3[CH2:13][CH:14]([C:16]4[CH:21]=[CH:20][C:19]([O:22][C:23]([F:25])([F:24])[F:26])=[C:18]([CH3:27])[CH:17]=4)[CH2:15][N:10]([C:8]([N:5]4[CH2:6][CH2:7][CH:2]([OH:1])[CH2:3][CH2:4]4)=[O:9])[CH2:11]3)[O:30][N:32]=2)[CH2:37][CH2:36]1

Participants

Reactant 2

HCID 2794666N'-Hydroxycyclopropanecarboximidamide

HCID 58002557HCID 58002557, compound

Product 1

HCID 58002657HCID 58002657, compound

Procedure

100 mg (0.22 mmol) of the compound from Example 170A and 33 mg (0.331 mmol) of N′-hydroxycyclopropanecarboximidamide were reacted according to the General Method 2. Yield: 41 mg (37% of theory)

Sources & evidence

ORD record: ord-453a03a6d95748c885779fccd8b1483f
Source dataset: uspto-grants-2012_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08119663B2

Reaction notes

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