(1E)-N'-Hydroxy-3-methoxypropanimidamide hydrochloride → HCID 58002397, compound

HRID 1643017Notes

Reaction equation

HRID 1643017 reaction equation
[OH:1][CH:2]1[CH2:7][CH2:6][N:5]([C:8]([N:10]2[CH2:15][CH:14]([C:16]3[CH:21]=[CH:20][C:19]([O:22][C:23]([F:26])([F:25])[F:24])=[C:18]([CH3:27])[CH:17]=3)[CH2:13][CH:12]([C:28]([OH:30])=O)[CH2:11]2)=[O:9])[CH2:4][CH2:3]1.O[N:32]=[C:33]([NH2:38])[CH2:34][CH2:35][O:36][CH3:37]>>[OH:1][CH:2]1[CH2:3][CH2:4][N:5]([C:8]([N:10]2[CH2:15][CH:14]([C:16]3[CH:21]=[CH:20][C:19]([O:22][C:23]([F:24])([F:26])[F:25])=[C:18]([CH3:27])[CH:17]=3)[CH2:13][CH:12]([C:28]3[O:30][N:38]=[C:33]([CH2:34][CH2:35][O:36][CH3:37])[N:32]=3)[CH2:11]2)=[O:9])[CH2:6][CH2:7]1

Participants

3

Reactant 2

HCID 4390391(1E)-N'-Hydroxy-3-methoxypropanimidamide hydrochlorideHCID 58002557HCID 58002557, compound

Product 1

HCID 58002397HCID 58002397, compound

Procedure

100 mg (0.221 mmol) of the compound from Example 170A and 52 mg (0.331 mmol) of the compound from Example 64A were reacted according to the General Method 2. Yield: 39 mg (35% of theory)

Sources & evidence

ORD record
ord-da575ac281b74a878e7915e8a659e4ad
Source dataset
uspto-grants-2012_02
Patent number
US08119663B2

Reaction notes

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