3-fluoro-N'-hydroxybenzene-1-carboximidamide → HCID 58002459, compound

HRID 1643018Notes

Reaction equation

HRID 1643018 reaction equation
[CH3:1][C:2]1[CH:3]=[C:4]([CH:9]2[CH2:14][N:13]([C:15]([N:17]3[CH2:22][CH2:21][CH:20]([OH:23])[CH2:19][CH2:18]3)=[O:16])[CH2:12][CH:11]([C:24](O)=[O:25])[CH2:10]2)[CH:5]=[CH:6][C:7]=1[CH3:8].[F:27][C:28]1[CH:29]=[C:30]([C:34](=[N:36]O)[NH2:35])[CH:31]=[CH:32][CH:33]=1>>[CH3:1][C:2]1[CH:3]=[C:4]([CH:9]2[CH2:10][CH:11]([C:24]3[O:25][N:36]=[C:34]([C:30]4[CH:31]=[CH:32][CH:33]=[C:28]([F:27])[CH:29]=4)[N:35]=3)[CH2:12][N:13]([C:15]([N:17]3[CH2:22][CH2:21][CH:20]([OH:23])[CH2:19][CH2:18]3)=[O:16])[CH2:14]2)[CH:5]=[CH:6][C:7]=1[CH3:8]

Participants

3

Reactant 2

HCID 40909723-fluoro-N'-hydroxybenzene-1-carboximidamideHCID 58002307HCID 58002307, compound

Product 1

HCID 58002459HCID 58002459, compound

Procedure

80 mg (0.22 mmol) of the compound from Example 128A and 51 mg (0.33 mmol) of the compound from Example 73A were reacted according to the General Method 2. Yield: 69 mg (65% of theory)

Sources & evidence

ORD record
ord-44fc92f1374c4fe29549fc3a623824f8
Source dataset
uspto-grants-2012_02
Patent number
US08119663B2

Reaction notes

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