HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-Hydroxybutyramidine → Morpholin-4-yl{3-(3-propyl-1,2,4-oxadiazol-5-yl)-5-[4-(trifluoromethoxy)phenyl]piperidin-1-yl}-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-Hydroxybutyramidine | HCID 2794811 | — |
| Reactant | 1-(Morpholin-4-ylcarbonyl)-5-[4-(trifluoromethoxy)phenyl]piperidine-3-carboxylic acid | HCID 58002500 | — |
| Product | Morpholin-4-yl{3-(3-propyl-1,2,4-oxadiazol-5-yl)-5-[4-(trifluoromethoxy)phenyl]piperidin-1-yl}-methanone | HCID 58002278 | — |
Reaction Steps
150 mg (0.373 mmol) of the compound from Example 44A and 70 mg (0.746 mmol) of N′-hydroxybutanimidamide were reacted according to the General Method 2. Yield: 174 mg (93% of theory).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08119663B2 |
| Source dataset | uspto-grants-2012_02 |
| ORD ID | ord-1dfb92cad46a4585ad8d2ed1b190b977 |
| Source note | uspto-grants-2012_02 |