N'-hydroxy-3-(trifluoromethyl)benzimidamide → HCID 58002460, compound

HRID 1643028Notes

Reaction equation

HRID 1643028 reaction equation
[N:1]1([C:7]([N:9]2[CH2:14][CH:13]([C:15]3[CH:20]=[CH:19][C:18]([O:21][C:22]([F:25])([F:24])[F:23])=[CH:17][CH:16]=3)[CH2:12][CH:11]([C:26](O)=[O:27])[CH2:10]2)=[O:8])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.O[N:30]=[C:31]([C:33]1[CH:38]=[CH:37][CH:36]=[C:35]([C:39]([F:42])([F:41])[F:40])[CH:34]=1)[NH2:32]>>[N:1]1([C:7]([N:9]2[CH2:10][CH:11]([C:26]3[O:27][N:32]=[C:31]([C:33]4[CH:38]=[CH:37][CH:36]=[C:35]([C:39]([F:40])([F:41])[F:42])[CH:34]=4)[N:30]=3)[CH2:12][CH:13]([C:15]3[CH:16]=[CH:17][C:18]([O:21][C:22]([F:23])([F:24])[F:25])=[CH:19][CH:20]=3)[CH2:14]2)=[O:8])[CH2:2][CH2:3][O:4][CH2:5][CH2:6]1

Participants

3

Reactant 2

HCID 609330N'-hydroxy-3-(trifluoromethyl)benzimidamideHCID 580025001-(Morpholin-4-ylcarbonyl)-5-[4-(trifluoromethoxy)phenyl]piperidine-3-carboxylic acid

Product 1

HCID 58002460HCID 58002460, compound

Procedure

150 mg (0.20 mmol) of 1-(morpholin-4-ylcarbonyl)-5-[4-(trifluoromethoxy)phenyl]piperidine-3-carboxylic acid (Example 44A) and 114 mg (0.56 mmol, 1.5 eq.) of N′-hydroxy-3-(trifluoromethyl)benzenecarboximidamide were reacted according to the General Method 2. Yield: 123 mg (58% of theory).

Sources & evidence

ORD record
ord-5d456e67223c461384a8d3638f4eaa86
Source dataset
uspto-grants-2012_02
Patent number
US08119663B2

Reaction notes

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