1-(Morpholin-4-ylcarbonyl)-5-[4-(trifluoromethoxy)phenyl]piperidine-3-carboxylic acid → HCID 58002529, compound

HRID 1643030Notes

Reaction equation

HRID 1643030 reaction equation
[N:1]1([C:7]([N:9]2[CH2:14][CH:13]([C:15]3[CH:20]=[CH:19][C:18]([O:21][C:22]([F:25])([F:24])[F:23])=[CH:17][CH:16]=3)[CH2:12][CH:11]([C:26]([OH:28])=O)[CH2:10]2)=[O:8])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[F:29][C:30]1[C:31]([C:37](=[N:39]O)[NH2:38])=[N:32][CH:33]=[C:34]([F:36])[CH:35]=1>>[F:29][C:30]1[C:31]([C:37]2[N:38]=[C:26]([CH:11]3[CH2:12][CH:13]([C:15]4[CH:20]=[CH:19][C:18]([O:21][C:22]([F:25])([F:24])[F:23])=[CH:17][CH:16]=4)[CH2:14][N:9]([C:7]([N:1]4[CH2:6][CH2:5][O:4][CH2:3][CH2:2]4)=[O:8])[CH2:10]3)[O:28][N:39]=2)=[N:32][CH:33]=[C:34]([F:36])[CH:35]=1

Participants

3

Reactant 2

HCID 580025001-(Morpholin-4-ylcarbonyl)-5-[4-(trifluoromethoxy)phenyl]piperidine-3-carboxylic acidHCID 136395912HCID 136395912, compound

Product 1

HCID 58002529HCID 58002529, compound

Procedure

150 mg (0.20 mmol) of 1-(morpholin-4-ylcarbonyl)-5-[4-(trifluoromethoxy)phenyl]piperidine-3-carboxylic acid (Example 44A) and 91 mg (0.56 mmol) of 3,5-difluoro-N′-hydroxypyridine-2-carboximidamide were reacted according to the General Method 2. Yield: 131 mg (63% of theory).

Sources & evidence

ORD record
ord-c2951e3ab7d64e80bcb64b51ecfc8593
Source dataset
uspto-grants-2012_02
Patent number
US08119663B2

Reaction notes

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