N-Hydroxyacetamidine → HCID 58002468, compound

HRID 1643033Notes

Reaction equation

[OH:1][CH:2]1[CH2:7][CH2:6][N:5]([C:8]([N:10]2[CH2:15][CH:14]([C:16]3[CH:21]=[CH:20][CH:19]=[C:18]([C:22]([F:25])([F:24])[F:23])[CH:17]=3)[CH2:13][CH:12]([C:26](O)=[O:27])[CH2:11]2)=[O:9])[CH2:4][CH2:3]1.O[N:30]=[C:31]([NH2:33])[CH3:32]>>[OH:1][CH:2]1[CH2:7][CH2:6][N:5]([C:8]([N:10]2[CH2:15][CH:14]([C:16]3[CH:21]=[CH:20][CH:19]=[C:18]([C:22]([F:24])([F:25])[F:23])[CH:17]=3)[CH2:13][CH:12]([C:26]3[O:27][N:33]=[C:31]([CH3:32])[N:30]=3)[CH2:11]2)=[O:9])[CH2:4][CH2:3]1

Participants

Reactant 2

HCID 30926N-Hydroxyacetamidine

HCID 58002715HCID 58002715, compound

Product 1

HCID 58002468HCID 58002468, compound

Procedure

150 mg (0.34 mmol) of the compound from Example 150A and 39 mg (0.51 mmol) of N′-hydroxyacetamidine were reacted according to the General Method 2. Yield: 71 mg (48% of theory)

Sources & evidence

ORD record: ord-1f1f79dd20594581a3fec520674c1549
Source dataset: uspto-grants-2012_02
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08119663B2

Reaction notes

Loading…